Fig. 4. HDAC2 overexpression in endothelium protects mice from atherosclerotic plaque burden. (A) Atherosclerotic plaques were measured by Oil red O staining in isolated aortas from C57BL/6 and HDAC2-Tg (Tie2) mice that were induced to develop atherosclerosis via liver-specific PCSK9 overexpression and a high-fat diet for 12 weeks. (B) Quantification of plaque from experiment in A. **p<0.05 vs control C57BL/6 mice fed a normal diet; ##p<0.05 vs atherogenic C57BL/6 mice (n=3).